周蝶;徐伟辉;王鹏;陈伊灵;何杰;

• 1:湖南中医药大学
• 2:湖南中医药高等专科学校附属第一医院

摘要(Abstract)：

目的:观察盘龙灸治疗慢性疲劳综合征(chronic fatigue syndrome,CFS)的临床疗效。方法:将80例CFS患者按照随机数字表法分为治疗组和对照组,每组40例。治疗组采用盘龙灸治疗,对照组采用电针治疗。比较两组患者的临床疗效及治疗前后疲劳量表-14、疲劳评定量表评分变化情况,检测两组患者治疗前后白细胞介素-2(interleukin-2,IL-2)、白细胞介素-6(interleukin-6,IL-6)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平变化情况。结果:两组患者治疗后疲劳量表-14和疲劳评定量表评分低于本组治疗前,且治疗组治疗后低于对照组治疗后,差异均有统计学意义(P<0.05)。两组患者治疗后IL-2高于本组治疗前,且治疗组治疗后高于对照组治疗后;两组患者治疗后IL-6、TNF-α低于本组治疗前,且治疗组治疗后低于对照组治疗后,差异均有统计学意义(P<0.05)。对照组有效率为87.50%,治疗组有效率为95.00%,两组患者有效率比较,差异具有统计学意义(P<0.05)。结论:盘龙灸可能通过抑制IL-6、TNF-α的表达,促进IL-2的表达,调节机体免疫功能,改善CFS患者疲劳状态。

关键词(KeyWords)： 慢性疲劳综合征;盘龙灸;电针疗法

Abstract:

Keywords:

基金项目(Foundation): 2018湖南省中医药科研计划项目(201877)

作者(Author): 周蝶;徐伟辉;王鹏;陈伊灵;何杰;

Email:

DOI: 10.16367/j.issn.1003-5028.2021.02.0061

参考文献(References)：

• [1] 赵彩霞.慢性疲劳综合征的研究现状[J].菏泽学院学报,2018,40(5):60-64.
• [2] 袁萍,梁伯衡.慢性疲劳综合征的流行病学特征[J].国外医学(卫生学分册),2003(2):70-74.
• [3] FUKUDA K,STRAUS S E,HICKIE I,et al.The chronic fatigue syndrome:a comprehensive approach to its definition and study.International Chronic Fatigue Syndrome Study Group[J].Ann Intern Med,1994,121(12):953-959.
• [4] 谭惠娟,罗婷婷,瞿玉竹,等.基于数据挖掘的针灸治疗慢性疲劳综合征腧穴运用规律[J].中国中医基础医学杂志,2017,23(2):242-244,298.
• [5] 张议文,张春萍,陈丽,等.针灸治疗慢性疲劳综合征取穴规律探析[J].针灸临床杂志,2015,31(12):59-61.
• [6] 王京京,王巧妹,孟宏,等.针灸治疗慢性疲劳综合征施治规律探讨[J].中国中医药信息杂志,2010,17(1):102-105.
• [7] 张建斌,王玲玲,吴焕淦,等.艾灸温通温补概念的内涵分析[J].中国针灸,2012,32(11):1000-1003.
• [8] 常小荣,刘密,严洁,等.艾灸温补作用的理论探源[J].中华中医药学刊,2011,29(10):2166-2168.
• [9] 高西绪,孙永宁,闫春妮.艾灸关元、气海穴对恶性肿瘤晚期患者生存质量及T淋巴细胞亚群的影响[J].中国中医急症,2017,26(3):542-544.
• [10] ZHANG D,YANG Y T,LIN J N,et al.Regulatory effect of moxibustion for rats with ulcerative colitis on the macrophage functional phenotype protein of lung tissue[J].J Acupunct Tuina Sci,2016,14(1):1-9.
• [11] 姚斐,赵毅,蒋诗超,等.从足太阳膀胱经论治慢性疲劳综合征的理论依据[J].中国针灸,2015,35(3):295-298.
• [12] PETERSEN K K,ROUSING M L,JENSEN C,et al.Effect of local controlled heat on transdermal delivery of nicotine[J].Int J Physiol Pathophysiol Pharmacol,2011,3(3):236-242.
• [13] 潘传芳,薛海燕,沈克平,等.艾灸改善胃癌患者免疫功能及生活质量的研究[J].上海针灸杂志,2013,32(9):726-728.
• [14] 黄畅,蒋洁,刘钧天,等.艾灸及艾烟对化疗所致白细胞减少症模型小鼠的影响[J].中华中医药杂志,2016,31(8):3220-3223.
• [15] 罗玳红,黄琼,吕细华,等.扶阳灸对脾肾阳虚型慢性疲劳综合征患者血清白细胞介素2、γ-干扰素水平的影响[J].河北中医,2017,39(11):1726-1729.
• [16] SHEN J,PENG Y,SHI D M,et al.The effects of moxibustion on serum interleukins and T cell subset in h.polyri infected rats[J].J Acupunct Herbs,2015,3(1):38-45.
• [17] 聂红梅,张欣,袁春华.腹灸法对中老年人机体免疫功能的影响[J].中国老年学杂志,2013,33(12):6288-6289.
• [18] TORRES-HARDING S,SORENSON M,JASON L A,et al.Evidence for T-helper 2 shift and association with illness parameters in chronic fatigue syndrome (CFS)[J].Bull IACFS ME,2008,16(3):19-33.
• [19] CABANAS H,MURAKI K,EATON N,et al.Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients[J].Mol Med,2018,24(1):44.
• [20] MEHALICK M L,SCHMALING K B,SABATH D E,et al.Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome[J].Fatigue:Biomed Heal Behav,2018,6(2):80-91.
• [21] FUITE J,VERNON S D,BRODERICK G.Neuroendocrine and immune network re-modeling in chronic fatigue syndrome:an exploratory analysis[J].Genomics,2008,92(6):393-399.
• [22] WYLLER V B,VITELLI V,SULHEIM D,et al.Altered neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue syndrome:a cross-sectional study[J].J Transl Med,2016,14(1):121.
• [23] 侯晓勇,贾广坡,田连营,等.慢性疲劳综合征发病相关机制探讨[J].河北医药,2015,37(16):2463-2466.
• [24] NIJS J,MEEUS M,MCGREGOR N R,et al.Chronic fatigue syndrome:exercise performance related to immune dysfunction[J].Med Sci Sports Exerc,2005,37(10):1647-1654.
• [25] MILRAD S F,HALL D L,JUTAGIR D R,et al.Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women[J].J Neuroimmunol,2017,303(2):43-50.
• [26] MILRAD S F,HALL D L,JUTAGIR D R,et al.Depression,evening salivary cortisol and inflammation in chronic fatigue syndrome:a psychoneuroendocrinological structural regression model[J].Int J Psychophysiol,2018,131(9):124-130.
• [27] 王欣,张建英,张玉芳,等.温针灸对亚健康肝气虚证职场女性T细胞亚群及细胞因子水平的影响[J].世界中西医结合杂志,2013,8(10):1019-1021.
• [28] 杨燕,李超然,王德龙,等.电针对慢性疲劳综合征大鼠学习记忆能力及血清细胞因子分泌的影响[J].神经损伤与功能重建,2019,14(11):541-543.
• [29] 华金双,邵伯雍,傅文.逆针灸对慢性疲劳大鼠行为学及IL-1β、IL-6的影响[J].中医研究,2017,30(4):73-76.
• [30] 罗英华,陈敏聪,冯耀华,等.针刺对慢性疲劳大鼠血清IL-2及TNF-α的影响[J].天津中医药,2006,23(3):206-208.